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Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

BACKGROUND: Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies to stimulate anti-cancer T cell responses, y...

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Podrobná bibliografie
Vydáno v:J Hematol Oncol
Hlavní autoři: De Santo, Carmela, Cheng, Paul, Beggs, Andrew, Egan, Sharon, Bessudo, Alberto, Mussai, Francis
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960181/
https://ncbi.nlm.nih.gov/pubmed/29776373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0612-6
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