Structural model of human dUTPase in complex with a novel proteinaceous inhibitor

Human deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase), essential for DNA integrity, acts as a survival factor for tumor cells and is a target for cancer chemotherapy. Here we report that the Staphylococcal repressor protein Stl(SaPIBov1) (Stl) forms strong complex with human dUTPase. Func...

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Publicat a:Sci Rep
Autors principals: Nyíri, Kinga, Mertens, Haydyn D. T., Tihanyi, Borbála, Nagy, Gergely N., Kőhegyi, Bianka, Matejka, Judit, Harris, Matthew J., Szabó, Judit E., Papp-Kádár, Veronika, Németh-Pongrácz, Veronika, Ozohanics, Olivér, Vékey, Károly, Svergun, Dmitri I., Borysik, Antoni J., Vértessy, Beáta G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847570/
https://ncbi.nlm.nih.gov/pubmed/29531348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22145-8
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