Crystal structure of the human 5-HT(1B) serotonin receptor bound to an inverse agonist

5-hydroxytryptamine (5-HT, also known as serotonin) regulates many physiological processes through the 5-HT receptor family. Here we report the crystal structure of 5-HT(1B) subtype receptor (5-HT(1B)R) bound to the psychotropic serotonin receptor inverse agonist methiothepin (MT). Crystallization w...

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Gepubliceerd in:Cell Discov
Hoofdauteurs: Yin, Wanchao, Zhou, X. Edward, Yang, Dehua, de Waal, Parker W., Wang, Meitian, Dai, Antao, Cai, Xiaoqing, Huang, Chia-Ying, Liu, Ping, Wang, Xiaoxi, Yin, Yanting, Liu, Bo, Zhou, Yu, Wang, Jiang, Liu, Hong, Caffrey, Martin, Melcher, Karsten, Xu, Yechun, Wang, Ming-Wei, Xu, H. Eric, Jiang, Yi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847559/
https://ncbi.nlm.nih.gov/pubmed/29560272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-018-0009-2
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