Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors

The glucagon receptor (GCGR) belongs to the secretin-like (class B) family of G protein-coupled receptors (GPCRs) and is activated by the peptide hormone glucagon. The structures of an activated class B GPCR have remained unsolved, preventing a mechanistic understanding of how these receptors are ac...

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Publicado no:J Biol Chem
Main Authors: Yin, Yanting, de Waal, Parker W., He, Yuanzheng, Zhao, Li-Hua, Yang, Dehua, Cai, Xiaoqing, Jiang, Yi, Melcher, Karsten, Wang, Ming-Wei, Xu, H. Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473240/
https://ncbi.nlm.nih.gov/pubmed/28356352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782987
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