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Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics
Hypoxia inducible factors (HIFs) are transcription factors belonging to the basic helix−loop−helix PER-ARNT-SIM (bHLH-PAS) protein family with a role in sensing oxygen levels in the cell. Under hypoxia, the HIF-α degradation pathway is blocked and dimerization with the aryl hydrocarbon receptor nucl...
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| Publicado en: | PLoS Comput Biol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5847239/ https://ncbi.nlm.nih.gov/pubmed/29489822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006021 |
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