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Metadynamics-Based Approaches for Modeling the Hypoxia-Inducible Factor 2α Ligand Binding Process

[Image: see text] Several methods based on enhanced-sampling molecular dynamics have been proposed for studying ligand binding processes. Here, we developed a protocol that combines the advantages of steered molecular dynamics (SMD) and metadynamics. While SMD is proposed for investigating possible...

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Publicat a:J Chem Theory Comput
Autors principals: Callea, Lara, Bonati, Laura, Motta, Stefano
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280741/
https://ncbi.nlm.nih.gov/pubmed/34082524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.1c00114
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