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Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods
The Pregnane X Receptor (PXR) is a ligand-activated transcription factor belonging to the nuclear receptor family. PXR can bind diverse drugs and environmental toxicants with different binding modes, making it an intriguing target for drug discovery. Here we investigated the binding mechanism of the...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6212460/ https://ncbi.nlm.nih.gov/pubmed/30385820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34373-z |
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