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Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods

The Pregnane X Receptor (PXR) is a ligand-activated transcription factor belonging to the nuclear receptor family. PXR can bind diverse drugs and environmental toxicants with different binding modes, making it an intriguing target for drug discovery. Here we investigated the binding mechanism of the...

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書目詳細資料
發表在:Sci Rep
Main Authors: Motta, Stefano, Callea, Lara, Giani Tagliabue, Sara, Bonati, Laura
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212460/
https://ncbi.nlm.nih.gov/pubmed/30385820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34373-z
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