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Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods

The Pregnane X Receptor (PXR) is a ligand-activated transcription factor belonging to the nuclear receptor family. PXR can bind diverse drugs and environmental toxicants with different binding modes, making it an intriguing target for drug discovery. Here we investigated the binding mechanism of the...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Motta, Stefano, Callea, Lara, Giani Tagliabue, Sara, Bonati, Laura
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212460/
https://ncbi.nlm.nih.gov/pubmed/30385820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34373-z
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