Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease

Sickle cell disease (SCD) results from a point mutation in the β-globin gene forming hemoglobin S (HbS), which polymerizes in deoxygenated erythrocytes, triggering recurrent painful vaso-occlusive crises and chronic hemolytic anemia. Reactivation of fetal Hb (HbF) expression ameliorates these sympto...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Krishnamoorthy, Sriram, Pace, Betty, Gupta, Dipti, Sturtevant, Sarah, Li, Biaoru, Makala, Levi, Brittain, Julia, Moore, Nancy, Vieira, Benjamin F., Thullen, Timothy, Stone, Ivan, Li, Huo, Hobbs, William E., Light, David R.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846716/
https://ncbi.nlm.nih.gov/pubmed/29046485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96409
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