Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

The autophagy-lysosome pathway (ALP) regulates intracellular homeostasis of the cytosolic protein SNCA/alpha-synuclein and is impaired in synucleinopathies, including Parkinson disease and dementia with Lewy bodies (DLB). Emerging evidence suggests that ALP influences SNCA release, but the underlyin...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Minakaki, Georgia, Menges, Stefanie, Kittel, Agnes, Emmanouilidou, Evangelia, Schaeffner, Iris, Barkovits, Katalin, Bergmann, Anna, Rockenstein, Edward, Adame, Anthony, Marxreiter, Franz, Mollenhauer, Brit, Galasko, Douglas, Buzás, Edit Irén, Schlötzer-Schrehardt, Ursula, Marcus, Katrin, Xiang, Wei, Lie, Dieter Chichung, Vekrellis, Kostas, Masliah, Eliezer, Winkler, Jürgen, Klucken, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846507/
https://ncbi.nlm.nih.gov/pubmed/29198173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1395992
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