Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity

BACKGROUND: Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson’s disease (PD). A novel H50Q mutation of aSyn, resulting in the substitution of histidine by glutamine, has recently been identi...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Xiang, Wei, Menges, Stefanie, Schlachetzki, Johannes CM, Meixner, Holger, Hoffmann, Anna-Carin, Schlötzer-Schrehardt, Ursula, Becker, Cord-Michael, Winkler, Jürgen, Klucken, Jochen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365527/
https://ncbi.nlm.nih.gov/pubmed/25886189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0004-0
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