Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

Cell-to-cell propagation of aggregated alpha synuclein (aSyn) has been suggested to play an important role in the progression of alpha synucleinopathies. A critical step for the propagation process is the accumulation of extracellular aSyn within recipient cells. Here, we investigated the traffickin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hoffmann, Anna-Carin, Minakaki, Georgia, Menges, Stefanie, Salvi, Rachele, Savitskiy, Sergey, Kazman, Aida, Vicente Miranda, Hugo, Mielenz, Dirk, Klucken, Jochen, Winkler, Jürgen, Xiang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345801/
https://ncbi.nlm.nih.gov/pubmed/30679445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35811-8
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