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Residue Histidine 50 Plays a Key Role in Protecting α-Synuclein from Aggregation at Physiological pH
α-Synuclein (αSyn) aggregation is involved in the pathogenesis of Parkinson disease (PD). Recently, substitution of histidine 50 in αSyn with a glutamine, H50Q, was identified as a new familial PD mutant. Here, nuclear magnetic resonance (NMR) studies revealed that the H50Q substitution causes an in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140903/ https://ncbi.nlm.nih.gov/pubmed/24742669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544049 |
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