Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating SNCA species are degraded by the autophagy-lysosomal pathway (ALP). Previously, we have shown that the ALP is not only responsible for SNCA d...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Poehler, Anne-Maria, Xiang, Wei, Spitzer, Philipp, May, Verena Elisabeth Luise, Meixner, Holger, Rockenstein, Edward, Chutna, Oldriska, Outeiro, Tiago Fleming, Winkler, Juergen, Masliah, Eliezer, Klucken, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502760/
https://ncbi.nlm.nih.gov/pubmed/25484190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.36436
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