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In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges

The successful use of CRISPR/Cas9 based gene editing for therapeutics requires efficient in vivo delivery of the CRISPR components. There are, however, major challenges on the delivery front. In this Topical Review, we will highlight recent developments in CRISPR delivery, and we will present hurdle...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Mout, Rubul, Ray, Moumita, Lee, Yi-Wei, Scaletti, Federica, Rotello, Vincent M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846329/
https://ncbi.nlm.nih.gov/pubmed/28263568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00057
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