In Vivo Editing of Macrophages through Systemic Delivery of CRISPR-Cas9-Ribonucleoprotein-Nanoparticle Nanoassemblies

Macrophages are key effectors of host defense and metabolism, making them promising targets for transient genetic therapy. Gene editing through delivery of the Cas9-ribonucleoprotein (RNP) provides multiple advantages over gene delivery-based strategies for introducing CRISPR machinery to the cell....

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Publicado en:Adv Ther (Weinh)
Main Authors: Lee, Yi-Wei, Mout, Rubul, Luther, David C., Liu, Yuanchang, Castellanos-García, Laura, Burnside, Amy S., Ray, Moumita, Tonga, Gulen Yeşilbag, Hardie, Joseph, Nagaraj, Harini, Das, Riddha, Phillips, Erin L., Tay, Tristan, Vachet, Richard W., Rotello, Vincent M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177476/
https://ncbi.nlm.nih.gov/pubmed/34095457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.201900041
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