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A General Strategy for Direct Cytoplasmic Protein Delivery via Protein-Nanoparticle Co-Engineering

Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles. The proteins feature an oligo(glutamate) sequence (E-tag) tha...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:ACS Nano
Päätekijät: Mout, Rubul, Ray, Moumita, Tay, Tristan, Sasaki, Kanae, Tonga, Gulen Yesilbag, Rotello, Vincent M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766003/
https://ncbi.nlm.nih.gov/pubmed/28614657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b02884
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