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A General Strategy for Direct Cytoplasmic Protein Delivery via Protein-Nanoparticle Co-Engineering
Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles. The proteins feature an oligo(glutamate) sequence (E-tag) tha...
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| Publicado no: | ACS Nano |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5766003/ https://ncbi.nlm.nih.gov/pubmed/28614657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b02884 |
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