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A General Method for Intracellular Protein Delivery through ‘E-tag’ Protein Engineering and Arginine Functionalized Gold Nanoparticles

In this protocol, we describe a method for direct cytosolic protein delivery that avoids endosomal entrapment of the delivered proteins. We achieved this by tagging the desired protein with an oligo glutamic acid tag (E-tag), and subsequently using carrier gold nanoparticles to deliver these E-tagge...

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Detalhes bibliográficos
Publicado no:Bio Protoc
Main Authors: Mout, Rubul, Rotello, Vincent M.
Formato: Artigo
Idioma:Inglês
Publicado em: Bio-Protocol 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760992/
https://ncbi.nlm.nih.gov/pubmed/29333478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.2661
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