Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

Lignende værker

• Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)
  af: Jansson, Patric J., et al.
  Udgivet: (2015)
• Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter
  af: Seebacher, Nicole A., et al.
  Udgivet: (2016)
• P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration
  af: Yamagishi, Tetsuo, et al.
  Udgivet: (2013)
• The Anticancer Agent Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Prosurvival Autophagy by Two Mechanisms: PERSISTENT INDUCTION OF AUTOPHAGOSOME SYNTHESIS AND IMPAIRMENT OF LYSOSOMAL INTEGRITY
  af: Gutierrez, Elaine, et al.
  Udgivet: (2014)
• Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding
  af: Park, Kyung Chan, et al.
  Udgivet: (2020)