Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

Multidrug resistance (MDR) is a major obstacle in cancer treatment due to the ability of tumor cells to efflux chemotherapeutics via drug transporters (e.g. P-glycoprotein (Pgp; ABCB1)). Although the mechanism of Pgp-mediated drug efflux is known at the plasma membrane, the functional role of intrac...

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Vydáno v:J Biol Chem
Hlavní autoři: Al-Akra, Lina, Bae, Dong-Hun, Sahni, Sumit, Huang, Michael L. H., Park, Kyung Chan, Lane, Darius J. R., Jansson, Patric J., Richardson, Des R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846167/
https://ncbi.nlm.nih.gov/pubmed/29305422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772699
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