Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

IQ motif–containing GTPase-activating proteins (IQGAPs) are scaffolding proteins playing central roles in cell–cell adhesion, polarity, and motility. The Rho GTPases Cdc42 and Rac1, in their GTP-bound active forms, interact with all three human IQGAPs. The IQGAP–Cdc42 interaction promotes metastasis...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ozdemir, E. Sila, Jang, Hyunbum, Gursoy, Attila, Keskin, Ozlem, Li, Zhigang, Sacks, David B., Nussinov, Ruth
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Computational Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846150/
https://ncbi.nlm.nih.gov/pubmed/29358323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001596
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