Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays

[Image: see text] A miniaturized assay was optimized to evaluate the enhanced apparent water solubility of pyrazolo[3,4-d]pyrimidine derivatives used extensively as anticancer drug scaffolds. The applied amount of drugs used in the reported strategy ranged from 5 to 10 μg per formulation which were...

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Publicado en:ACS Med Chem Lett
Main Authors: Sanna, Monica, Sicilia, Giovanna, Alazzo, Ali, Singh, Nishant, Musumeci, Francesca, Schenone, Silvia, Spriggs, Keith A., Burley, Jonathan C., Garnett, Martin C., Taresco, Vincenzo, Alexander, Cameron
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2018
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846050/
https://ncbi.nlm.nih.gov/pubmed/29541359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00456
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