Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors

[Image: see text] Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcome the lack of favorable ADME properties, in particular aqueous solubility and bioavailability. We report herein the successful application of this strategy with two representative py...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Vignaroli, Giulia, Zamperini, Claudio, Dreassi, Elena, Radi, Marco, Angelucci, Adriano, Sanità, Patrizia, Crespan, Emmanuele, Kissova, Miroslava, Maga, Giovanni, Schenone, Silvia, Musumeci, Francesca, Botta, Maurizio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2013
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027536/
https://ncbi.nlm.nih.gov/pubmed/24900720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000782
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak