Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors

[Image: see text] Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcome the lack of favorable ADME properties, in particular aqueous solubility and bioavailability. We report herein the successful application of this strategy with two representative py...

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Main Authors: Vignaroli, Giulia, Zamperini, Claudio, Dreassi, Elena, Radi, Marco, Angelucci, Adriano, Sanità, Patrizia, Crespan, Emmanuele, Kissova, Miroslava, Maga, Giovanni, Schenone, Silvia, Musumeci, Francesca, Botta, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027536/
https://ncbi.nlm.nih.gov/pubmed/24900720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000782
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