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Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors
[Image: see text] Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcome the lack of favorable ADME properties, in particular aqueous solubility and bioavailability. We report herein the successful application of this strategy with two representative py...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2013
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027536/ https://ncbi.nlm.nih.gov/pubmed/24900720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000782 |
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