Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

Pyrazolo[3,4-d]pyrimidines are a class of compounds with a good activity against several cancer cell lines. Despite the promising anticancer activity, these molecules showed a poor aqueous solubility. This issue could threat the future development of pyrazolo[3,4-d]pyrimidines as clinical drug candi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Vignaroli, Giulia, Calandro, Pierpaolo, Zamperini, Claudio, Coniglio, Federica, Iovenitti, Giulia, Tavanti, Matteo, Colecchia, David, Dreassi, Elena, Valoti, Massimo, Schenone, Silvia, Chiariello, Mario, Botta, Maurizio
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761914/
https://ncbi.nlm.nih.gov/pubmed/26898318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21509
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