Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme

[Image: see text] Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor. Residual cells at the tumor margin are responsible for up to 85% of GBM recurrences after standard treatment. Despite this evidence, the identification of compounds active on this cell population is still an...

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Publicado en:ACS Med Chem Lett
Main Authors: Greco, Chiara, Taresco, Vincenzo, Pearce, Amanda K., Vasey, Catherine E., Smith, Stuart, Rahman, Ruman, Alexander, Cameron, Cavanagh, Robert J., Musumeci, Francesca, Schenone, Silvia
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2020
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236042/
https://ncbi.nlm.nih.gov/pubmed/32435367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00530
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