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Linker Variation and Structure–Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors
[Image: see text] The molecular determinants for the activities of the reported benzoic acid (SH4–54), salicylic acid (BP-1–102), and benzohydroxamic acid (SH5–07)-based STAT3 inhibitors were investigated to design optimized analogues. All three leads are based on an N-methylglycinamide scaffold, wi...
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| Pubblicato in: | ACS Med Chem Lett |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2018
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846032/ https://ncbi.nlm.nih.gov/pubmed/29541369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00544 |
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