Linker Variation and Structure–Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors

[Image: see text] The molecular determinants for the activities of the reported benzoic acid (SH4–54), salicylic acid (BP-1–102), and benzohydroxamic acid (SH5–07)-based STAT3 inhibitors were investigated to design optimized analogues. All three leads are based on an N-methylglycinamide scaffold, wi...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Lopez-Tapia, Francisco, Brotherton-Pleiss, Christine, Yue, Peibin, Murakami, Heide, Costa Araujo, Ana Carolina, Reis dos Santos, Bruna, Ichinotsubo, Erin, Rabkin, Anna, Shah, Raj, Lantz, Megan, Chen, Suzie, Tius, Marcus A., Turkson, James
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846032/
https://ncbi.nlm.nih.gov/pubmed/29541369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00544
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