Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity

α-Synuclein (α-Syn) is intimately linked to the etiology of Parkinson's Disease, as mutations and even subtle increases in gene dosage result in early onset of the disease. However, how this protein causes neuronal dysfunction and neurodegeneration is incompletely understood. We thus examined a...

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Foilsithe in:Front Mol Neurosci
Main Authors: Tolö, Johan, Taschenberger, Grit, Leite, Kristian, Stahlberg, Markus A., Spehlbrink, Gesche, Kues, Janina, Munari, Francesca, Capaldi, Stefano, Becker, Stefan, Zweckstetter, Markus, Dean, Camin, Bähr, Mathias, Kügler, Sebastian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845890/
https://ncbi.nlm.nih.gov/pubmed/29563864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00049
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