Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity

α-Synuclein (α-Syn) is intimately linked to the etiology of Parkinson's Disease, as mutations and even subtle increases in gene dosage result in early onset of the disease. However, how this protein causes neuronal dysfunction and neurodegeneration is incompletely understood. We thus examined a...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Tolö, Johan, Taschenberger, Grit, Leite, Kristian, Stahlberg, Markus A., Spehlbrink, Gesche, Kues, Janina, Munari, Francesca, Capaldi, Stefano, Becker, Stefan, Zweckstetter, Markus, Dean, Camin, Bähr, Mathias, Kügler, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845890/
https://ncbi.nlm.nih.gov/pubmed/29563864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00049
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