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Nanogel-DFO Conjugates as a Model to Investigate Pharmacokinetics, Biodistribution, and Iron Chelation In Vivo

Deferoxamine (DFO) to treat iron overload (IO) has been limited by toxicity issues and short circulation times and it would be desirable to prolong circulation to improve non-transferrin bound iron (NTBI) chelation. In addition, DFO is currently unable to efficiently target the large pool of iron in...

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Bibliografiske detaljer
Udgivet i:Int J Pharm
Main Authors: Wang, Yan, Liu, Zhi, Lin, Tien-Min, Chanana, Shaurya, Xiong, May P.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845769/
https://ncbi.nlm.nih.gov/pubmed/29341909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2018.01.004
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