S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4–ERK1/2 Signaling

Myeloid-derived suppressor cells (MDSCs) often expand during cancer or chronic inflammation and dampen immune responses. However, mechanisms underlying their capacity to escape intrinsic apoptosis in the inflammatory environment are still largely unknown. In this study, we investigated this in mouse...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Li, Qingcui, Dai, Chengliang, Xue, Rui, Wang, Peigang, Chen, Lin, Han, Yijie, Erben, Ulrike, Qin, Zhihai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845385/
https://ncbi.nlm.nih.gov/pubmed/29556233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00388
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