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Comparative assessment of strategies to identify similar ligand-binding pockets in proteins

BACKGROUND: Detecting similar ligand-binding sites in globally unrelated proteins has a wide range of applications in modern drug discovery, including drug repurposing, the prediction of side effects, and drug-target interactions. Although a number of techniques to compare binding pockets have been...

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Bibliografiske detaljer
Udgivet i:BMC Bioinformatics
Main Authors: Govindaraj, Rajiv Gandhi, Brylinski, Michal
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845264/
https://ncbi.nlm.nih.gov/pubmed/29523085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2109-2
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