Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair

Mismatched nucleotides arise from polymerase misincorporation errors, recombination between heteroallelic parents and chemical or physical DNA damage(1). Highly conserved MutS (MSH) and MutL (MLH/PMS) homologues initiate mismatch repair and, in higher eukaryotes, act as DNA damage sensors that can t...

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Udgivet i:Nature
Main Authors: Liu, Jiaquan, Hanne, Jeungphill, Britton, Brooke M., Bennett, Jared, Kim, Daehyung, Lee, Jong-Bong, Fishel, Richard
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845140/
https://ncbi.nlm.nih.gov/pubmed/27851738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20562
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