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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair
Mismatched nucleotides arise from polymerase misincorporation errors, recombination between heteroallelic parents and chemical or physical DNA damage(1). Highly conserved MutS (MSH) and MutL (MLH/PMS) homologues initiate mismatch repair and, in higher eukaryotes, act as DNA damage sensors that can t...
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| Pubblicato in: | Nature |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5845140/ https://ncbi.nlm.nih.gov/pubmed/27851738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20562 |
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