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ATP Alters the Diffusion Mechanics of MutS on Mismatched DNA
The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps on DNA: a transient mismatch searching clamp (~1 s) and an unusually stable (~600 s) ATP-bound clamp that recruits downstream MMR components. Remarkably, direct visualization of single MutS particles on mism...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974879/ https://ncbi.nlm.nih.gov/pubmed/22682745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.04.017 |
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