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Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

Darunavir (DRV) has bimodal activity against HIV-1 protease, enzymatic inhibition and protease dimerization inhibition, and has an extremely high genetic barrier against development of drug resistance. We previously generated a highly DRV-resistant HIV-1 variant (HIV(DRV)(R)(P51)). We also reported...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:mBio
Κύριοι συγγραφείς: Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844992/
https://ncbi.nlm.nih.gov/pubmed/29511083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02425-17
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