Synergistic targeting of the regulatory and catalytic subunits of PI3Kδ in mature B cell malignancies

PURPOSE: Aberrant activation of the B cell receptor (BCR) is implicated in the pathogenesis of mature B-cell tumors, a concept validated in part by the clinical success of inhibitors of the BCR-related kinases BTK (Bruton’s tyrosine kinase) and PI3Kδ (Phosphatidylinositol-4,5-bisphosphate 3-kinase d...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Cooney, Jeffrey D., Lin, An-Ping, Jiang, Daifeng, Wang, Long, Suhasini, Avvaru N., Myers, Jamie, Qiu, ZhiJun, Wölfler, Albert, Sill, Heinz, Aguiar, Ricardo C.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844841/
https://ncbi.nlm.nih.gov/pubmed/29246942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2218
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