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The N-terminal region of DNA polymerase δ catalytic subunit is necessary for holoenzyme function

Genetic and biochemical studies have shown that DNA polymerase δ (Polδ) is the major replicative Pol in the eukaryotic cell. Its functional form is the holoenzyme composed of Polδ, proliferating cell nuclear antigen (PCNA) and replication factor C (RF-C). In this paper, we describe an N-terminal tru...

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Udgivet i:Nucleic Acids Res
Principais autores: Schumacher, Sylvie Briand, Stucki, Manuel, Hübscher, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10606663/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.2.620
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