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Biophysical and Biological Evaluation of Optimized Stapled Peptide Inhibitors of the Linear Ubiquitin Chain Assembly Complex (LUBAC)

Linear ubiquitylation, in which ubiquitin units are covalently linked through N- and C-terminal amino acids, is a unique cellular signaling mechanism. This process is controlled by a single E3 ubiquitin ligase, the linear ubiquitin chain assembly complex (LUBAC), which is composed of three proteins...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Aguilar-Alonso, Francisco, Whiting, Amanda L., Kim, Ye Joon, Bernal, Federico
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844832/
https://ncbi.nlm.nih.gov/pubmed/29246782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.11.047
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