Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Constitutive activation of NF-κB is a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), owing to upstream signals from the B cell receptor (BCR) and MyD88 pathways. The linear polyubiquitin chain assembly complex (LUBAC) attaches linear polyubiquitin chain...

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Autori principali: Yang, Yibin, Schmitz, Roland, Mitala, Joseph, Whiting, Amanda, Xiao, Wenming, Ceribelli, Michele, Wright, George W., Zhao, Hong, Yang, Yandan, Xu, Weihong, Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Braziel, Rita M., Tubbs, Raymond R., Cook, James. R., Weisenburger, Dennis D., Chan, Wing C., Wiestner, Adrian, Kruhlak, Michael J., Iwai, Kazuhiro, Bernal, Federico, Staudt, Louis M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992927/
https://ncbi.nlm.nih.gov/pubmed/24491438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0915
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