Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Constitutive activation of NF-κB is a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), owing to upstream signals from the B cell receptor (BCR) and MyD88 pathways. The linear polyubiquitin chain assembly complex (LUBAC) attaches linear polyubiquitin chain...

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Autors principals: Yang, Yibin, Schmitz, Roland, Mitala, Joseph, Whiting, Amanda, Xiao, Wenming, Ceribelli, Michele, Wright, George W., Zhao, Hong, Yang, Yandan, Xu, Weihong, Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Braziel, Rita M., Tubbs, Raymond R., Cook, James. R., Weisenburger, Dennis D., Chan, Wing C., Wiestner, Adrian, Kruhlak, Michael J., Iwai, Kazuhiro, Bernal, Federico, Staudt, Louis M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992927/
https://ncbi.nlm.nih.gov/pubmed/24491438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0915
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