Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2–HO-1 pathway in renal proximal tubular cells of transgenic mice

INTRODUCTION: We aimed to examine the regulation of aquaporin 1 expression in an angiotensinogen transgenic mouse model, focusing on underlying mechanisms. METHODS: Male transgenic mice overexpressing rat angiotensinogen in their renal proximal tubular cells (RPTCs) and rat immortalised RPTCs stably...

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Détails bibliographiques
Publié dans:J Renin Angiotensin Aldosterone Syst
Auteurs principaux: Chang, Shiao-Ying, Lo, Chao-Sheng, Zhao, Xin-Ping, Liao, Min-Chun, Chenier, Isabelle, Bouley, Richard, Ingelfinger, Julie R, Chan, John SD, Zhang, Shao-Ling
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2016
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843896/
https://ncbi.nlm.nih.gov/pubmed/27638854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1470320316668737
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