Catalase Prevents Maternal Diabetes–Induced Perinatal Programming via the Nrf2–HO-1 Defense System

We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring of nondiabetic and diabetic dams from two transgenic (Tg) lines (Hoxb7-gre...

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Détails bibliographiques
Auteurs principaux: Chang, Shiao-Ying, Chen, Yun-Wen, Zhao, Xin-Ping, Chenier, Isabelle, Tran, Stella, Sauvé, Alexandre, Ingelfinger, Julie R., Zhang, Shao-Ling
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2012
Sujets:
Pathophysiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447903/
https://ncbi.nlm.nih.gov/pubmed/22733796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0248
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