Angiotensin II Type II Receptor Deficiency Accelerates the Development of Nephropathy in Type I Diabetes via Oxidative Stress and ACE2

Since the functional role(s) of angiotensin II (Ang II) type II receptor (AT(2)R) in type I diabetes is unknown, we hypothesized that AT(2)R is involved in decreasing the effects of type I diabetes on the kidneys. We induced diabetes with low-dose streptozotocin (STZ) in both AT(2)R knockout (AT(2)R...

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Détails bibliographiques
Auteurs principaux: Chang, Shiao-Ying, Chen, Yun-Wen, Chenier, Isabelle, Tran, Stella Le Minh, Zhang, Shao-Ling
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205615/
https://ncbi.nlm.nih.gov/pubmed/22110472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/521076
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