Angiotensin-II mediates ACE2 Internalization and Degradation through an Angiotensin-II type I receptor-dependent mechanism

Angiotensin Converting Enzyme type 2 (ACE2) is a pivotal component of the renin-angiotensin system, promoting the conversion of Angiotensin (Ang)-II to Ang-(1-7). We previously reported that decreased ACE2 expression and activity contribute to the development of Ang-II-mediated hypertension in mice....

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Bibliografiska uppgifter
I publikationen:Hypertension
Huvudupphovsmän: Deshotels, Matthew R., Xia, Huijing, Sriramula, Srinivas, Lazartigues, Eric, Filipeanu, Catalin M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231883/
https://ncbi.nlm.nih.gov/pubmed/25225202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03743
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