Catalase Prevents Maternal Diabetes–Induced Perinatal Programming via the Nrf2–HO-1 Defense System

We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring of nondiabetic and diabetic dams from two transgenic (Tg) lines (Hoxb7-gre...

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Detalles Bibliográficos
Main Authors: Chang, Shiao-Ying, Chen, Yun-Wen, Zhao, Xin-Ping, Chenier, Isabelle, Tran, Stella, Sauvé, Alexandre, Ingelfinger, Julie R., Zhang, Shao-Ling
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2012
Assuntos:
Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447903/
https://ncbi.nlm.nih.gov/pubmed/22733796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0248
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