The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers

Antibody affinity maturation occurs in germinal centres (GC) where B cells cycle between the light zone (LZ) and the dark zone. In the LZ GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from T helper cells that promotes their rapid prolifer...

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Publicat a:Nat Immunol
Autors principals: Monzón-Casanova, Elisa, Screen, Michael, Díaz-Muñoz, Manuel D., Coulson, Richard M. R., Bell, Sarah E., Lamers, Greta, Solimena, Michele, Smith, Christopher W.J., Turner, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842895/
https://ncbi.nlm.nih.gov/pubmed/29358707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-017-0035-5
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