The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

Robust innate immune detection of rapidly evolving pathogens is critical for host defense. Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate immune sensors in plants and animals. However, the structural basis for ligand-induced NLR activation has so far remain...

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Veröffentlicht in:Science
Hauptverfasser: Tenthorey, Jeannette L., Haloupek, Nicole, López-Blanco, José Ramón, Grob, Patricia, Adamson, Elise, Hartenian, Ella, Lind, Nicholas A., Bourgeois, Natasha M., Chacón, Pablo, Nogales, Eva, Vance, Russell E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842810/
https://ncbi.nlm.nih.gov/pubmed/29146805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao1140
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