Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1) leads to cancer immune evasion via inhibition of T cell function. One of the defining characteristics of glioblastoma, a universally fatal brain cancer, is its profound local and systemic immunosuppression. Gliobla...

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發表在:Sci Adv
Main Authors: Ricklefs, Franz L., Alayo, Quazim, Krenzlin, Harald, Mahmoud, Ahmad B., Speranza, Maria C., Nakashima, Hiroshi, Hayes, Josie L., Lee, Kyungheon, Balaj, Leonora, Passaro, Carmela, Rooj, Arun K., Krasemann, Susanne, Carter, Bob S., Chen, Clark C., Steed, Tyler, Treiber, Jeffrey, Rodig, Scott, Yang, Katherine, Nakano, Ichiro, Lee, Hakho, Weissleder, Ralph, Breakefield, Xandra O., Godlewski, Jakub, Westphal, Manfred, Lamszus, Katrin, Freeman, Gordon J., Bronisz, Agnieszka, Lawler, Sean E., Chiocca, E. Antonio
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2018
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842038/
https://ncbi.nlm.nih.gov/pubmed/29532035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar2766
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