Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O(6)-methylguanine DNA methyltransferase) and APNG (alkylpurine-DNA-N-glycosylase) are key enzymes capable of repairing temo...

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Publicado en:Nat Commun
Main Authors: Shao, Huilin, Chung, Jaehoon, Lee, Kyungheon, Balaj, Leonora, Min, Changwook, Carter, Bob S., Hochberg, Fred H., Breakefield, Xandra O., Lee, Hakho, Weissleder, Ralph
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430127/
https://ncbi.nlm.nih.gov/pubmed/25959588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7999
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