Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults

BACKGROUND. HIV-infected individuals, even well controlled with combined antiretroviral therapy (cART), have systemic inflammation and comorbidities. Substance P (SP) is an undecapeptide, which mediates neurotransmission and inflammation through its cognate neurokinin 1 receptor (NK1R). Plasma SP le...

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Vydáno v:JCI Insight
Hlavní autoři: Spitsin, Sergei, Tebas, Pablo, Barrett, Jeffrey S., Pappa, Vasiliki, Kim, Deborah, Taylor, Deanne, Evans, Dwight L., Douglas, Steven D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841871/
https://ncbi.nlm.nih.gov/pubmed/28978797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95893
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