The 4-N-Acyl and 4-N-Alkyl Gemcitabine Analogues with Silicon-Fluoride-Acceptor: Application to (18)F-Radiolabeling

The coupling of gemcitabine with functionalized carboxylic acids using peptide coupling conditions afforded 4-N-alkanoyl analogues with a terminal alkyne or azido moiety. Reaction of 4-N-tosylgemcitabine with azidoalkyl amine provided 4-N-alkyl gemcitabine with a terminal azido group. Click reaction...

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Publicat a:Eur J Med Chem
Autors principals: Gonzalez, Cesar, Sanchez, Andersson, Collins, Jeffrey, Lisova, Ksenia, Lee, Jason T., van Dam, R. Michael, Barbieri, M. Alejandro, Ramachandran, Cheppail, Wnuk, Stanislaw F.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841594/
https://ncbi.nlm.nih.gov/pubmed/29471120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.02.017
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